Wednesday, April 23, 2014
PLACERVILLE, CALIFORNIA
99 CENTS

Rock doc: Grapefruit + medications = potential problem

By
From page A4 | January 02, 2013 | 6 Comments

A breakfast of half a grapefruit and some peanut butter on a piece of toast sounds like it would be good for you, doesn’t it?

For millions of Americans who take prescription drugs, the answer may be no.

The difficulty arises because of certain effects in the compounds found in grapefruit and some other citrus fruits. When you eat them, they deactivate another chemical in the liver and small intestine that works to break down medication. The more such deactivation there is, the greater the effective dose of the medicine in your body because you aren’t breaking it down as you normally would.

“Taking one tablet with a glass of grapefruit juice is like taking five tablets with water,” said pharmacologist David Bailey when he spoke about the matter to the program NPR Shots.

And it seems the problem extends to more than just grapefruit. Seville oranges – which I love to eat at breakfast in tangy marmalade – may also act like grapefruit with respect to medications. So even something in your diet that seems as innocuous as toast and jam could be problematic.

If you are really dedicated to grapefruit consumption, your doctor may be able to substitute a new medication for one that’s problematic. But if you want to stay on your current meds, the wise decision may be to forego the grapefruit.

Lists on the web about what medications are problematic with grapefruit are evidently incomplete. You should therefore check with your doctor or pharmacist about your own medications. But here are some of the most commonly prescribed drugs that raise concerns with respect to grapefruit and certain other citrus products.

According to WebMD the drugs that can become problematic with respect to consuming grapefruit include:

Statins: Lipitor, Zocor and Mevacor

Impotence Drugs: Viagra

Psychiatric Drugs: Buspar, Valium, Zoloft

Pain Drugs: Methadone

Antihistimines: Ebastine

Anti-HIV medications: Invirase

Anti-arrhythmics: Cordarone

According to a Mayo Clinic Website other medications like this include:

Antihistamine: Allegra

Calcium channel blockers: Procardia, Nimotop and Sular

Anti-seizure medications: Tegretol

Immunosuppressants: Neoral, Sandimmune, Prograf and Rapamune

According to a recent NPR article other medications in this group include:

Cancer drugs: Tarceva

Antibiotic: Erythromycin

Blood thinner: Plavix, Brilinta

Anti-psychotic: Seroquel

But to repeat, it looks to me like all of the lists on the Web are incomplete. You need to investigate your own medications with your doctor or pharmacist. While you’re at it, confess to the authorities if you take herbal supplements or other similar substances. You might as well get them all checked out.

Dr. E. Kirsten Peters, a native of the rural Northwest, was trained as a geologist at Princeton and Harvard. This column is a service of the College of Agricultural, Human and Natural Resource Sciences at Washington State University.

E. Kirsten Peters

LEAVE A COMMENT

Discussion | 6 comments

  • Tom JohnsonDecember 22, 2012 - 3:55 pm

    Let me get this straight. If I take one viagra with grapefruit, it is equal to 5 viagras with water? Honey, pass the grapefruit, and brace yourself!

    Reply | Report abusive comment
  • cookie65January 03, 2013 - 10:17 am

    It is amazing the stuff my long ago departed grandmother used to tell me that end up being true. What did they know?, back then there were no signs in restrooms telling us to wash our hands. We are only a couple years shy of having instructions printed on toilet paper.

    Reply | Report abusive comment
  • EvelynJanuary 03, 2013 - 10:27 am

    Speaking of toilet paper: HERE (I almost linked this prior to Christmas, but fearing I'd lose my job of the Dem's local correspondent, I refrained!)

    Reply | Report abusive comment
  • cookie65January 03, 2013 - 1:11 pm

    Totally not right for him to lose his job over this. I can't think of a better use for that mug. If obama wants to wipe everyones backside for them we might as well make it a reality. It reminds me of an idea I had over a year ago. Obama's face on golf balls.

    Reply | Report abusive comment
  • EvelynJanuary 03, 2013 - 3:28 pm

    Pretty expensive at $5.99 a roll, but sometimes price just does not count. HERE

    Reply | Report abusive comment
  • merkabaJanuary 03, 2013 - 8:39 pm

    not listing benzo's? cimetidine also not mentioned wile also highlighting methadone and excluding other more common pain medications.. hydro/oxy codone... in fact the only real pain medication to exclude would be plain ol' codine because of the morphine conversion. But hey im not the doctor here.. dr. fragmented information md.

    Reply | Report abusive comment
.

News

Herard over the back fence: Try fishing at Wakamatsu

By Bob Billingsley | From Page: B1

 
Downtown group coordinates painting, awnings

By Wendy Schultz | From Page: A1

 
More mountain lion sightings reported

By Dawn Hodson | From Page: A1, 8 Comments

Supervisor Nutting trial begins

By Cole Mayer | From Page: A1, 63 Comments | Gallery

 
Sanford murder case to jury

By Cole Mayer | From Page: A1 | Gallery

 
Gearing tax questions to correct office saves time

By Treasurer-Tax Collector | From Page: A3

.

Opinion

My turn: More than a buzzword

By Special to the Democrat | From Page: A4, 23 Comments

 
Building restored

By Mountain Democrat | From Page: A4

 
Outstanding dog

By Mountain Democrat | From Page: A4

.

Letters

National Day of Prayer

By Letters to the Editor | From Page: A5, 1 Comment

 
‘Parents, be afraid’ letter

By Letters to the Editor | From Page: A5, 17 Comments

Ukranian situation

By Letters to the Editor | From Page: A5, 3 Comments

 
Misquote

By Letters to the Editor | From Page: A5, 8 Comments

Altshuler framing

By Letters to the Editor | From Page: A5, 6 Comments

 
.

Sports

Pitching the ‘Root’ cause of Trojans’ victory

By Mike Bush | From Page: A6 | Gallery

 
Pedal power at the forefront next month

By Jerry Heinzer | From Page: A6 | Gallery

Outside with Charlie: Transitioning

By Charlie Ferris | From Page: A6

 
Sports Scene: April 22, 2014

By Democrat Staff | From Page: A7

Roundup: April 22, 2014

By Democrat Staff | From Page: A7

 
.

Prospecting

4-H’ers star at showcase

By Dawn Hodson | From Page: B1 | Gallery

 
At a glance: Look for fireballs

By Mimi Escabar | From Page: B2, 1 Comment

Authors to share their stories

By Pat Lakey | From Page: B2, 2 Comments

 
Church to host human trafficking conference

By Pollock Pines | From Page: B3

Grow For It! Flower of Easter

By Barbara Schuchart | From Page: B5

 
.

Essentials

Crime Log: April 1-3

By Cole Mayer | From Page: A2

 
Weather stats 4-22-14

By Michael Raffety | From Page: A2

Building permits 4/7-11/2014

By Michael Raffety | From Page: A2

 
.

Obituaries

Bobby Lloyd Bridges

By Contributor | From Page: A2

 
Harry Frank Harper

By Contributor | From Page: A2, 6 Comments

Marion “Wayne” Griswold

By Contributor | From Page: A2

 
.

Real Estate

.

Comics

Rubes

By Contributor | From Page: A8

 
New York Times Crossword

By Contributor | From Page: A8

Flying McCoys

By Contributor | From Page: A8

 
Speed Bump

By Contributor | From Page: A8

Tundra

By Contributor | From Page: A8

 
Horoscope, Thursday, April 24, 2014

By Contributor | From Page: A8

Horoscope, Wednesday, April 23, 2014

By Contributor | From Page: A8

 
Working It Out

By Contributor | From Page: A8

TV Listings

By Contributor | From Page: A8

 
Shoe

By Contributor | From Page: A8

Sudoku

By Contributor | From Page: A8